Prophylaxis of hereditary breast cancer

Prophylaxis of hereditary breast cancer

Hereditary Breast-Ovarian Cancer

Management of Hereditary Breast Cancer

D.M. Eccles, P. Simmonds, J. Goddard, M. Coultas, F. Lalloo, G. Evans and N. Haites in collaboration with the European Familial Breast Cancer Collaborative Group Department of Clinical Genetics, Princess Ann Hospital, Coxford Road, Southampton, UK Medical Oncology, Royal South Hants Hospital, Southampton, UK Medical Statistics and Computing, Southampton General Hospital, Southampton, UK Clinica...

Hereditary breast and ovarian cancer

Familial breast cancer was first recognized in the Roman medical literature of 100 AD [1]. The first documentation of familial clustering of breast cancer in modern times was published by Broca, who reported 10 cases of breast cancer in 4 generations of his wife’s family [2]. In the middle of the nineteen nineties it was proven at the molecular level that a substantial number of breast and ovar...

Gene assembling: a new approach in molecular diagnosis of hereditary breast cancer

 Abstract Background: Many disease susceptibility genes are large and consist of many exons in which point mutations are scattered throughout. Scanning each exon individually represents a tedious task which can be time consuming and expensive. There has been increasing demand for rapid and accurate methods for full scanning of unknown point mutations in large multi-exon genes. Gene Assembling i...